Tamoxifen Citrate Powder Quick Detail:
Tamoxifen Citrate Powder
Appearance:White crystalline powder
Delivery time:5-7 business days door to door
Usage:Tamoxifen Citrate is suitable for the treatment of advanced breast cancer and ovarian cancer. Pregnancy category D, pregnant and lactating women disabled. It generally affects in 4 ~ 10 weeks in patients, but the curative effect of metastatic bone lesions may work later. Non hormonal contraception measures should be adopted during treatment .
Tamoxifen Citrate Description:
Tamoxifen Citrate is a nonsteroidal agent which has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects may be related to its ability to compete with estrogen for binding sites in target tissues such as breast. Tamoxifen inhibits the induction of rat mammary carcinoma induced by dimethylbezanthracene (DMBA) and causes the regression of already established DMBA-induced tumors. In this rat model, tamoxifen appears to exert its antitumor effects by binding the estrogen receptors. It is also recognized that tamoxifen displays estrogenic like effects on several sites including the endometrium, bone and lipids.
Tamoxifen is extensively metabolized after oral administration. Studies in women reviewing 20 mg of 14C tamoxifen have shown that approximately 65% of the administered dose was excreted from the body over a period of 2 weeks with fecal excretion as the primary route of elimination. The drug was excreted mainly as polar conjugates, with unchanged drug and unconjugated metabolites accounting for less than 30% of the total fecal radioactivity.
Tamoxifen Citrate Applications:
Tamoxifen Citrate Tablets are indicated for the treatment of axillary node- negative breast cancer in women following total mastectomy or segmental mastectomy, axillary dissection and breast irradiation. Data are insufficient to predict which women are most likely to benefit and to determine if Tamoxifen Citrate Tablets provide any benefit in women with tumors less than 1 cm.
Tamoxifen Citrate Tablets are indicated for the treatment of node-positive breast cancer in postmenopausal women following total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation. In some Tamoxifen Citrate adjuvant studies, most of the benefit to date has been in the subgroup with 4 or more positive axillary nodes.
The estrogen and progesterone receptor values may help to predict whether adjuvant Tamoxifen Citrate therapy is likely to be beneficial.
Tamoxifen Citrate Specifications:
|Product name||Tamoxifen citrate (Nolvadex)|
|Appearance||White crystalline powder|
|Identification||IR , UV conform||Conform|
|Loss on drying||≤0.5ml||0.21ml|
|Residue on ignition||Not more than 0.2%||0.07ml|
|Iron||Not more than 0.005%||0.0017%|
|Heavy metals||Not more than 0.001%||0.0006%|
|Related substances||Total: Not more than 1.0%Individual: Not more than 0.5%||0.35%0.13%|
|E-isomer||Not more than 0.3%||0.18%|
|Organic volatile impurities||Conforms||Conforms|
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Packaging Details: 1kg/foil bag or as required
Delivery Time: Within 24 hours after receiving the payment
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 5000kg/month