Tetracaine Hydrochloride Application

Tetracaine (INN,also known as amethocaine; trade name Pontocaine.Ametop and Dicaine) is a potent local anesthetic of the ester group.It is mainly used topically in ophthalmology and as an antipruritic,and it has been used in spinal anesthesia.
In biomedical research,tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores.Tetracaine is an allosteric blocker of channel function.At low concentrations,tetracaine causes an initial inhibition of spontaneous calcium release events,while at high concentrations,tetracaine blocks release completely.

Tetracaine Hydrochloride Usage

Tetracaine hydrochloride has been used for studying the pharmacological effects of spinal anesthesia.A crystalline compound related to procaine and used as a local anesthetic.

Tetracaine Hydrochloride COA
Test Items Specification Test Results
Appearance Fine,white,crystalline,odorless powder confirm
Identification ABC in Pass confirm
Solubility Very soluble in water,soluble in Alcohol;
insoluble in Ether and Benzene
confirm
USP Reference standards USP Tetracaine Hydrochloride RS.
USP Endotoxin RS.
confirm
Melting point 145~150 degree 146.0~147.5
degree
Chromatographic purity In Pass confirm
Related substance Not more than the reference solution 0.05% confirm
Heavy metals ≤10ppm confirm
PH 4.5-6.5 5.8
Residue on ignition ≤0.10% 0.05%
Loss on Drying ≤ 0.5% 0.19%
Assay 98.0 -101.0% 100.1%
Conclusion Confirms USP 32