Tetracaine Hydrochloride Application
Tetracaine (INN,also known as amethocaine; trade name Pontocaine.Ametop and Dicaine) is a potent local anesthetic of the ester group.It is mainly used topically in ophthalmology and as an antipruritic,and it has been used in spinal anesthesia.
In biomedical research,tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores.Tetracaine is an allosteric blocker of channel function.At low concentrations,tetracaine causes an initial inhibition of spontaneous calcium release events,while at high concentrations,tetracaine blocks release completely.
Tetracaine Hydrochloride Usage
Tetracaine hydrochloride has been used for studying the pharmacological effects of spinal anesthesia.A crystalline compound related to procaine and used as a local anesthetic.
Tetracaine Hydrochloride COA
|Test Items||Specification||Test Results|
|Identification||ABC in Pass||confirm|
|Solubility||Very soluble in water,soluble in Alcohol;
insoluble in Ether and Benzene
|USP Reference standards||USP Tetracaine Hydrochloride RS.
USP Endotoxin RS.
|Melting point||145~150 degree||146.0~147.5
|Chromatographic purity||In Pass||confirm|
|Related substance||Not more than the reference solution 0.05%||confirm|
|Residue on ignition||≤0.10%||0.05%|
|Loss on Drying||≤ 0.5%||0.19%|
|Conclusion||Confirms USP 32|